SKU: 19544516133

TMEM149/IGFLR1 Fc Chimera Protein, Human

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Description

TMEM149/IGFLR1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms U2AF1L4 Accession Q9H665 Amino Acid Sequence Ser23 Pro163, with C hIgG1 Fc Expression System HEK293 Molecular Weight 43 55kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability & Storage 12

Product Specification


Species Human
Synonyms U2AF1L4
Accession Q9H665
Amino Acid Sequence Ser23-Pro163, with C-hIgG1 Fc
Expression System HEK293
Molecular Weight 43-55kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

Wenjing Song, Xin He, Pengju Gong, Yan Yang, Sirui Huang, Yifan Zeng, Jingwei Zhang. IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. Front Mol Biosci. 2020 Nov 26;7:565173.eCollection 2020.

Background

Insulin Growth Factor-Like receptor 1 (IGFLR1), also known as transmembrane protein 149 (TMEM149), is a protein encoding gene located on chromosome 19 and is widely expressed in lymph nodes, spleen and kidney. Although studies have shown that high expression level of IGFLR1 could predict poor survival among patients with ccRCC (Clear cell renal cell carcinoma), the mechanism of the cancer-promoting effect of IGFLR1 has been still unclear and previous studies were limited to carbohydrate metabolism. Adrian et al. found that IGFLR1 was similar in structure to the tumor necrosis factor receptor family (TNFRs) and considered to be a novel receptor in the TNFRs. IGFLR1 may be a tumor immune-related molecule. However, the potential function and prognostic value of IGFLR1 in tumor progression and tumor immunology remained unclear.

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SKU: 19544516133

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4.8 ★★★★★
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Verified Purchase
Wilbur F. Pierce
Louisville, US
★★★★★ 5
An Excellent Choice
Format: Paperback
Excellent introduction, notes and translation.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 8, 2017
D
Verified Purchase
David Lemberg
Omaha, US
★★★★★ 5
Five Stars
Format: Paperback
Professor Cornford's translation with running commentary is definitive.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 5, 2015
J
Jordan Bell
Lake Worth, US
★★★★★ 5
Plato's dialogue about the physical world
Format: Paperback
The two biggest topics in the Timaeus are astronomy and the elements of bodies, which are constructed using triangles and the tetrahedron, octahedron, icosahedron, and cube. I would like to see a translation of the Timaeus that uses it as a way to introduce all the astronomy that appears in the dialogue. Introducing the astronomy does not mean just talking in words about spheres or the zodiac or the ecliptic, but actually explaining how these were used by astronomers. Cornford has much to say, but to someone who has not learned any Greek astronomy his commentary will be opaque and hard to use. I didn't know the astronomy well enough to readily understand Cornford's explanations. I plan to learn more classical Greek astronomy, perhaps using Evans' , and then read Waterfield's translation of the Timaeus . Before reading this you should have read the Republic and know some classical Greek natural philosophy, mathematics, and astronomy. Although Cornford's commentary makes the dialogue staccato, I am glad for it because I wouldn't otherwise have understood much of what Plato says. The Timaeus and the Parmenides are the two dialogues of Plato that one needs commentary to understand; the Parmenides demands the commentary because so much of what is happening depends on the original language, and the Timaeus demands the commentary because of all the things the reader is supposed to be familiar with. The following is a list of topics I kept while reading the dialogue: theory of Forms 27d-28a, 51a-52a; harmonics 35b-36b; time 37c-38e, 39b-e; vision 45b-46c, 67c-68d; space 52b; surfaces 53c; weight 62d-63e; sound 67a-67c; physiology 70c-79e, 80d-86a; antiperistasis 79e-80c.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 12, 2015
S
Steve Lookner
Birmingham, US
★★★★★ 4
Helpful, but Waterfield is better for an intro
Format: Paperback
This is basically a scholarly paragraph-by-paragraph commentary on the Timaeus. It's really good for what it is, but I don't recommend it as your first introduction to the Timaeus -- rather, I recommend Waterfield: http://www.amazon.com/Timaeus-Critias-Oxford-Worlds-Classics-ebook/dp/B006NTMD16 A problem with using Cornford as an introduction is that he comments on everything, and it's hard to figure out what the main themes are. I tried reading Cornford as an intro and gave it up, but once I'd read Waterfield I found Cornford extremely helpful both in elucidating passages further than Waterfield does, and in interpreting passages Waterfield doesn't cover. So if you're looking to learn about the Timaeus, I'd suggest Waterfield first and Cornford second (or Cornford alongside Waterfield).
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 24, 2014
B
Brian Chrzastek
Chelsea, US
★★★★★ 5
Cornford's running commentary is arguably the best suited to fulfill this desire
Readers of any of Plato's works are bound to feel they might profit from various commentaries. His Timaeus, in particular, may be said to elicit such a hope because of number and intricacy of its details. Cornford's running commentary is arguably the best suited to fulfill this desire: it helps make clear the integrity of the dialogue as a whole and illumines the specific points along the way. Although this work is certainly dated, originally published in 1937, it is certainly one of the best full commentaries on the Timaeus.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 4, 2014

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